Christina Choe's debut feature Nancy premiered at Sundance in the 2018 US Dramatic Competition, where it won the Waldo Salt Best Screenplay Award. The film stars Andrea Riseborough, Steve Buscemi, Ann Dowd, John Leguizamo, J. Smith-Cameron and was produced in partnership with EON Productions' Barbara Broccoli and Michael G. Wilson.

Nancy was nominated for 2 Independent Spirit Awards and named one of the "Best films of 2018" by Indiewire, The Village Voice and the A/V Club, with Choe also being named one of Indiewire's "20 Rising Female Directors."

In 2017, Choe's docu-series Welcome to the DPRK, a personal portrait of North Korea, was acquired by First Look Media/Topic Studios and is currently streaming online.

Choe is currently developing her next feature film, an original TV series, and most recently directed episodes of Hulu’s The Act, and Jordan Peele’s reboot of The Twilight Zone.