David and Lou are best friends. David keeps getting stood up by girls, and Lou always comes to the rescue, encouraging him to keep trying. One day a girl finally shows up, and David and Lou begin to drift apart as David becomes invested in his new relationship. Lou is left to deal with his own struggles alone. Can their friendship still be saved? 'Call Me When You Get This' is a comedy/drama that explores friendships and relationships and how one affects the other.